RESEARCH · SOURCE DOCUMENTS

Technology in context.
Information with a source.

From live-source extraction to separation and purification, explore four technical patent records listed in the supplied documents, with clear identifiers, bibliographic context and published sources.

2003Leech cultivation and live-source hirudin extraction
2011A production method for natural hirudin
2014Large-scale production of natural hirudin
2021Large-scale hirudin separation, purification and equipment
A patent is technical information, not evidence of a product effect.These are background-document and published-patent references. They do not establish that either represented product uses the process, has identical specifications or holds Hong Kong product approval. They do not establish ownership by HONGKIU or a brand-owning business.
ZL03113566.8Public record cross-checked

Leech cultivation and live-source hirudin extraction

The published text describes staged leech cultivation and breeding, induction of saliva secretion from live leeches, and subsequent filtration, separation and purification. It also describes returning leeches to cultivation for repeat extraction. This summarizes a preparation technique, not clinical evidence for an oral finished product.

Publication / grant record
CN1423929A / CN1273012C

Applicant & dates
Original applicant: Zhou Weihai, as listed in the published record
Filed: 15 Jan 2003; published: 18 Jun 2003; grant publication: 6 Sep 2006
Source and reading notes
The application publication and grant publication use different titles within the same application history. The supplied image follows the grant title concerning extraction from live leeches. Current ownership and legal status have not been officially verified.

Original source: company-supplied certificate image covering four hirudin technologies, compared with published patent texts.

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ZL201110237495.6Public record cross-checked

A production method for natural hirudin

The process covers extraction and filtration of a natural-hirudin-containing liquid, acid precipitation, heat treatment, pH adjustment, centrifugation and concentration, followed by addition of a water-soluble excipient and freeze-drying to form a powder. The text also describes thrombin titration for measuring hirudin content.

Publication / grant record
CN102286098A / CN102286098B

Applicant & dates
Published record lists an individual applicant; inventors: Zhou Weihai and Zhou Weiguan
Filed: 18 Aug 2011; published: 21 Dec 2011; grant publication: 4 Sep 2013
Source and reading notes
Bibliographic information and technical text have been cross-checked. Website ownership and status fields do not replace a current official register, and do not establish use of this process in a represented product.

Original source: company-supplied certificate image covering four hirudin technologies, compared with published patent texts.

Read the published patent ↗
ZL201410402315.9Public record cross-checked

Large-scale production of natural hirudin

The disclosed method induces saliva release from live blood-sucking leeches, collects crude hirudin liquid, then filters it, adds a filler and dries it into powder. It also describes rinsing and continued cultivation for repeat extraction, as well as freeze-drying or spray-drying conditions.

Publication / grant record
CN104151425A / CN104151425B

Applicant & dates
Original applicant: Zhou Weihai, as listed in the published record
Filed: 15 Aug 2014; published: 19 Nov 2014; grant publication: 8 Feb 2017
Source and reading notes
The application and grant texts have been cross-checked. Subsequent transfer or name-change entries have not been verified against a current official rights record; no ownership by HONGKIU is asserted.

Original source: company-supplied certificate image covering four hirudin technologies, compared with published patent texts.

Read the published patent ↗
ZL202110010624.1Public record cross-checked

Large-scale hirudin separation, purification and equipment

The text describes processing crude hirudin through acid precipitation, heating, cooling, solid/liquid separation, neutralization, microfiltration and nanofiltration, followed by collection and freeze-drying. Associated equipment includes process tanks, centrifuges, filtration units and product tanks, with return lines and selectable process routes.

Publication / grant record
CN112480243A / CN112480243B

Applicant & dates
Applicant: 廣西科康科技集團有限公司, as listed in the published record
Filed: 6 Jan 2021; published: 12 Mar 2021; grant publication: 5 May 2023
Source and reading notes
The supplied number was re-read at higher resolution as 202110010624.1, correcting an initial OCR reading. Technical or production statements in the patent are not independent testing or proof of current legal status.

Original source: company-supplied certificate image covering four hirudin technologies, compared with published patent texts.

Read the published patent ↗
READ THE EVIDENCE

Recognize the research.
Keep the evidence in perspective.

A disclosed technical process

A patent describes a claimed process or equipment scope; it is not independent testing of every finished product.

Current rights require a separate check

Applicants, transfers and validity should be checked against current official records. Google Patents status fields are indexing information, not legal advice.

Finished products need their own evidence

General hirudin research and patent text do not replace evidence for a specific oral formulation, dose and route.

Scope of this pageOn 29 October 2026, the supplied image references were compared with published texts indexed by Google Patents. No current, case-specific CNIPA legal-status certificate was obtained, and no conclusion is made about live rights, infringement, licensing or clinical use. Contact HONGKIU for formal patent or product documents.
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